Methyldopa EP Impurity D HBr CAS 2799-15-7 (free base)
| CAS No. | 2799-15-7 (free base) |
| Molecular Formula | C10H13NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Methyldopa EP Impurity D HBr (CAS 2799-15-7 (free base), C10H13NO4HBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Methyldopa EP Impurity D HBr (C10H13NO4HBr) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13NO4 HBr |
| Molecular Weight | 292.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Methyldopa Standards
- Methyldopa EP Impurity D (CAS 1369423-51-7)
- Methyldopa EP Impurity D (CAS 2799-15-7)
- Methyldopa EP Impurity B HCl (CAS 35026-10-9)
- Methyldopa EP Impurity C (CAS 39948-18-0)
- Methyldopa EP Impurity C (CAS 5486-79-3)
- DL-Methyldopa (CAS 55-40-3)
- Methyldopa EP Impurity A (CAS 6739-31-7)
- Methyldopa EP Impurity A (CAS 6739-31-7（free base）)
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